David K C Cooper Selected Research

Thrombosis (Thrombus)

10/2019	Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article.
5/2014	The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.
7/2012	Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.
6/2009	Coagulation dysregulation as a barrier to xenotransplantation in the primate.
9/2008	Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells.
11/2003	Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate.

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David K C Cooper Research Topics

Disease

18	Inflammation (Inflammations) 01/2021 - 09/2015
15	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 01/2008
14	Infections 03/2024 - 06/2003
14	Brain Death (Brain Dead) 12/2023 - 08/2005
12	Thrombotic Microangiopathies 08/2023 - 07/2003
11	Thrombocytopenia (Thrombopenia) 01/2022 - 11/2011
6	Congenital Heart Defects (Congenital Heart Defect) 12/2023 - 01/2017
6	Thrombosis (Thrombus) 10/2019 - 11/2003
5	Chronic Kidney Failure (Chronic Renal Failure) 08/2023 - 01/2019
4	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 11/2009
4	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2019 - 05/2004
3	Neoplasms (Cancer) 05/2023 - 09/2002
2	Membranous Glomerulonephritis (Membranous Nephropathy) 03/2024 - 08/2023
2	Proteinuria 03/2024 - 08/2023
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/2023 - 05/2004
2	Hypovolemia 01/2023 - 01/2021
2	Heart Failure 01/2023 - 01/2021
2	Hypertrophy 01/2021 - 01/2012
2	Hypoplastic Left Heart Syndrome 11/2020 - 02/2019
2	Reperfusion Injury 01/2020 - 01/2019
2	Blindness (Hysterical Blindness) 11/2015 - 03/2014
2	Corneal Diseases (Corneal Disease) 05/2014 - 03/2014
2	Hemorrhage 01/2012 - 07/2003
2	Disseminated Intravascular Coagulation 11/2006 - 11/2003
2	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2006 - 12/2004
1	Hypotension (Low Blood Pressure) 01/2023
1	Hemolysis 01/2023
1	Communicable Diseases (Infectious Diseases) 01/2023
1	Body Weight (Weight, Body) 01/2023
1	Hydronephrosis 11/2022
1	Hypercalcemia (Milk Alkali Syndrome) 11/2022
1	Hypophosphatemia 11/2022
1	Cytokine Release Syndrome 07/2022
1	Sickle Cell Anemia (Hemoglobin S Disease) 11/2021
1	Anemia 01/2021
1	Hypothermia 12/2020
1	Zoonoses 01/2020
1	COVID-19 01/2020
1	Corneal Opacity 11/2019
1	Vasculitis (Vasculitides) 10/2019
1	Frailty 01/2019

Drug/Important Bio-Agent (IBA)

7	AntibodiesIBA 08/2023 - 05/2004
7	Insulin (Novolin)FDA Link 11/2016 - 02/2006
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 06/2003
5	Thyroid HormonesIBA 01/2021 - 10/2014
5	Fibrinogen (Factor I)FDA Link 10/2019 - 05/2015
4	AntigensIBA 03/2024 - 06/2009
4	Immunoglobulin G (IgG)IBA 08/2023 - 08/2013
4	Interleukin-6 (Interleukin 6)IBA 07/2022 - 01/2017
4	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2016 - 10/2014
3	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2022 - 01/2019
3	Complement System Proteins (Complement)IBA 01/2020 - 01/2018
3	CytokinesIBA 01/2019 - 12/2006
3	Vasopressins (Vasopressin)IBA 01/2015 - 12/2006
3	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2015 - 10/2014
2	Heterophile AntigensIBA 08/2023 - 01/2023
2	HLA Antigens (Human Leukocyte Antigens)IBA 08/2023 - 11/2013
2	Immunoglobulin M (IgM)IBA 08/2023 - 01/2022
2	Histones (Histone)IBA 01/2020 - 10/2017
2	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020 - 11/2013
2	Interleukin-17 (Interleukin 17)IBA 01/2017 - 01/2017
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2015 - 11/2014
2	Streptozocin (Streptozotocin)FDA Link 01/2014 - 05/2007
2	Dacarbazine (DIC)FDA LinkGeneric 11/2006 - 11/2003
2	DNA (Deoxyribonucleic Acid)IBA 09/2003 - 05/2002
1	eculizumab FDA Link 03/2024
1	Monoclonal AntibodiesIBA 03/2024
1	Antigen-Antibody Complex (Immune Complex)IBA 08/2023
1	1,4-dihydro-N-methylnicotinamideIBA 08/2023
1	Immunosuppressive Agents (Immunosuppressants)IBA 05/2023
1	MTOR InhibitorsIBA 05/2023
1	Inulin FDA Link 01/2023
1	ReninIBA 01/2023
1	PotassiumIBA 01/2023
1	ElectrolytesIBA 11/2022
1	Etanercept (Enbrel)FDA Link 01/2021
1	CarbohydratesIBA 11/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020
1	InterleukinsIBA 01/2020

Therapy/Procedure

53	Heterologous Transplantation (Xenotransplantation) 12/2023 - 05/2002
26	Transplantation 01/2023 - 09/2004
19	Therapeutics 11/2022 - 07/2003
7	Organ Transplantation 01/2020 - 09/2002
6	Liver Transplantation 01/2022 - 11/2009
6	Islets of Langerhans Transplantation 01/2021 - 05/2007
5	Kidney Transplantation 01/2023 - 12/2018
4	Heart Transplantation (Grafting, Heart) 01/2023 - 09/2015
4	Corneal Transplantation (Keratoplasty) 11/2019 - 03/2014
3	Euthanasia (Mercy Killing) 12/2018 - 01/2012
2	Operative Surgical Procedures 01/2017 - 01/2016
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2016 - 10/2014
2	Resuscitation 01/2016 - 02/2008
1	Palliative Care (Palliative Therapy) 10/2022
1	Peritoneal Dialysis 01/2022
1	Renal Dialysis (Hemodialysis) 01/2022
1	Artificial Liver (Bioartificial Liver) 01/2022
1	Blood Transfusion (Blood Transfusions) 11/2021
1	Glycemic Control 01/2021
1	Heart-Lung Machine 12/2020
1	Immunomodulation 01/2019